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mda mb 453  (ATCC)


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    Structured Review

    ATCC mda mb 453
    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. <t>JIMT-1</t> <t>and</t> <t>MDA-MB-453</t> cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
    Mda Mb 453, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 2063 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mda mb 453/product/ATCC
    Average 98 stars, based on 2063 article reviews
    mda mb 453 - by Bioz Stars, 2026-03
    98/100 stars

    Images

    1) Product Images from "Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2-positive breast cancer"

    Article Title: Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2-positive breast cancer

    Journal: International Journal of Molecular Medicine

    doi: 10.3892/ijmm.2026.5751

    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. JIMT-1 and MDA-MB-453 cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
    Figure Legend Snippet: EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. JIMT-1 and MDA-MB-453 cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.

    Techniques Used: MTS Assay, Flow Cytometry, Microscopy, Expressing, Control



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    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. <t>JIMT-1</t> <t>and</t> <t>MDA-MB-453</t> cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
    Mda Mb 453, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. <t>JIMT-1</t> <t>and</t> <t>MDA-MB-453</t> cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
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    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. <t>JIMT-1</t> <t>and</t> <t>MDA-MB-453</t> cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
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    cell line nb 1  (ATCC)
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    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. <t>JIMT-1</t> <t>and</t> <t>MDA-MB-453</t> cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.
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    Image Search Results


    EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. JIMT-1 and MDA-MB-453 cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.

    Journal: International Journal of Molecular Medicine

    Article Title: Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2-positive breast cancer

    doi: 10.3892/ijmm.2026.5751

    Figure Lengend Snippet: EBA induces apoptosis in trastuzumab-resistant breast cancer cells. (A) Chemical structure of EBA. (B) Cell viability and IC 50 values were determined using the MTS assay. JIMT-1 and MDA-MB-453 cells were treated with EBA (48 h) and analyzed by flow cytometry to assess (C) sub-G1 phase populations and (D) early and late apoptotic cells. (E) Morphological changes in JIMT-1 cells following EBA treatment, observed by phase-contrast microscopy. Magnification, x200. (F) Effect of EBA on the expression of PARP, cleaved PARP, caspase-3, -7 and -8 and cleaved caspase-3, -7 and -8 in JIMT-1 cells. GAPDH was used as a loading control. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001 vs. vehicle-treated control (0 μ M EBA). EBA, ebastine.

    Article Snippet: The human breast cancer cell lines SKBR3, BT474, MDA-MB-453 (American Type Culture Collection) and JIMT-1 (Leibnitz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH) were cultured in DMEM, MEM or RPMI-1640 (all Sigma-Aldrich; Merck KGaA) supplemented with 10% FBS (Gibco; Thermo Fisher Scientific, Inc.) and 100 U/ml penicillin-streptomycin at 37°C in a humidified atmosphere of 5% CO 2 .

    Techniques: MTS Assay, Flow Cytometry, Microscopy, Expressing, Control